International Conference on Biomedical Ontology 2005

نویسندگان

  • Francisco Couto
  • Janna Hastings
  • Amanda Hicks
چکیده

Objectives: To (1) present an ontological framework for the TNM classifi-cation system, (2) implement a TNM ontology for colon and rectum tumorsbased on this framework, and (3) evaluate this ontology with a classifier forpathology data. Methods: The TNM ontology uses the Foundational Model of Anatomyfor anatomical entities and BioTopLite 2 as a domain top-level ontology.General rules for the TNM system and the specific TNM classification forcolorectal tumors were formulated. Additional information was collectedfrom tumor documentation practice in an academic Comprehensive CancerCenter. Based on the ontology, an automatic classifier for pathology datawas developed. Results: TNM was represented as an information artefact which consistsof single representational units. Corresponding to every representationalunit, tumors and tumor aggregates were defined. Tumor aggregates consistof the primary tumor and (if existent) of infiltrated regional lymph nodesand distant metastases. TNM codes depend on the location and certainqualities of the primary tumor (T), the infiltrated regional lymph nodes (N)and the existence of distant metastases (M). Tumor data from clinical andpathological documentation were successfully classified with the ontology. Conclusion: A first version of the TNM Ontology represents the TNM sys-tem for the description of the anatomical extent of malignant tumors. Thepresented work is already sufficient to show its representational correctnessand completeness as well as its applicability for classification of instancedata.

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تاریخ انتشار 2015